The ACLU of Indiana is overseen by a Board of Directors that consists of 12 regional directors, nine at-large directors and nine board-appointed directors. The Board of Directors meets at least three times a year to set policy, appoint the executive director as needed, acquire and dispose of property, and engage in other activities consistent with the mission of the organization. Directors serve three-year terms. Members of the Board of Directors receive no compensation for their services.

Current members of the Board of Directors include:
Caroline Richardson, President, Indianapolis
Tamara Winfrey-Harris, Vice-President, Indianapolis
Kevin McElmurry, Secretary, Gary
Cris Halter, Treasurer, Indianapolis
Georgia Cravey, Equity Officer, Indianapolis
Geraldine Chavez Mahoney, Mishawaka

Emma Crossen, Terre Haute
Robert Dion, Evansville
Luis Fuentes-Rohwer, Bloomington

Michael Grossberg, Bloomington
Kyle Grubbs, North Manchester
Greg Hasty, Fishers
Christopher Hegerty, Lafayette
Sara Hindi, Indianapolis
Terri R. Jett, Indianapolis
Mark Nicholson, Indianapolis

David Shircliff, Bedford
Reba Boyd Wooden, Greenwood
Ellen Wu, Bloomington